Oregon's game with USC Saturday November 22 has been set for 12:30 p.m. PT on CBS, live from Autzen Stadium in Eugene.
At FanDuel, the oddsmakers have installed the Ducks as a 7.5-point favorite. The over/under is 56.5 with the MoneyLine Oregon -315, USC +250.
The Ducks are 7-3 in the last 10 matchups with the Trojans, winners of the last three in a row. SC has not won in the series since a 45-20 win in Los Angeles in 2016. They last won in Eugene in 2011.
Lincoln Riley's squad lost at Illinois on September 27, 34-32. They lost at No. 9 Notre Dame 34-24 nearly a month ago on October 18. They've won three straight since the loss to the Irish.
On Saturday they overcame a 21-7 deficit to Iowa in the second quarter at home in The Coliseum, scoring the final 19 points to win 26-21.
The Trojans feature the nation's No. 3 offense at 7.43 yards per play. They rank No. 10 in scoring at 38.2 points per game. The defense is suspect, touched for 5.59 yards per play this season, 88th against the run giving up 4.42 yards per carry.
B1G one next Saturday in Autzen.
— Oregon Football (@oregonfootball) November 16, 2025
Ducks vs. Trojans will kick off at 12:30 PM on CBS. #GoDucks pic.twitter.com/BPK91wuxtj
It's a matchup of two of college football's top passers. Dante Moore ranks No. 4 in the FBS in passer rating at 168.6, a 72.8 percent passer who has thrown for 2,190 yards, 21 touchdowns with 5 interceptions. Maiava ranks eighth in efficiency at 162.56, 2,868 yards, 18 touchdowns, 6 interceptions.
Oddly, the narratives between the schools have flipped a bit. USC comes in as the underdog program with something to prove, up and coming and hungry. For years that was Oregon's role, but they've had more recent success.
The early weather forecast for the Eugene area for Saturday calls for a daytime high of 55, a couple of showers with minimal wind, evening temperatures in the high 40s, according to AccuWeather.
Adding juice to the matchup is that the Ducks are led by two former Trojans in offensive guard Emmanuel Pregnon and defensive tackle Bear Alexander. Several of Oregon's best players hail from Southern California, including Matayo Uiagalelei, Isaiah World and Gary Bryant Jr., another USC transfer.