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Oregon vs. USC: Last-Minute Odds, Predictions, and Gameday Updates

ByNicholas Rome
Oregon head coach Dan Lanning cheers on his team as the Oregon Ducks host the Portland State Vikings on Sept. 18, 2026, at Autzen Stadium in Eugene, Oregon.
Oregon head coach Dan Lanning cheers on his team as the Oregon Ducks host the Portland State Vikings on Sept. 18, 2026, at Autzen Stadium in Eugene, Oregon. | USA TODAY Network via Reuters Connect

On Saturday Night in the Big Ten, all eyes will be on a throwback Pac 12 showdown between the Oregon Ducks and the USC Trojans. The Top 25 clash carries massive stakes for both teams as the winner will have great resume building win, while the loser is going to have to walk a tightrope the rest of the way.

Dan Lanning has gotten the best of Lincoln Riley when they've faced off with a 2-0 record, but this season feels as if both coaches have arguably their most talented rosters at their respective schools. This game could come down to the final possesion, and it has all the potential to be one of the best games of the season.

Oregon game day guide: Odds, weather, injury updates, and more

Oregon Vs USC odds

As of Saturday Morning, the Ducks are 3.5 point favorites over the Trojans (-106) according to FanDuel Sportsbook. Oregon is currently -170 favorites to win the game, while USC is a +140 underdog. The total is set at 61.5 points (-110). The Ducks entering game day as 3.5 point favorites is notable as the initial line to start the week began at 2.5 points.

All odds and lines are subject to change.

Los Angeles, California weather forecast for Saturday

After a cooler Friday night in Eugene, fans in attendance and the players will be treated to much warmer weather this weekend in Los Angeles. On Saturday, temperatures are expected to be in the high 70s earlier in the day before rising into the 80s around kickoff and cooling off later in the evening. There also shouldn't be any weather delays, with just a 10% chance of precipitation currently in the forecast.

Injury Updates

This weekend, Oregon provides its first injury report of the season as Big Ten play begins, creating more transparency on the status of several players. On the Oregon side, the two biggest names to watch are tight ends Jamari Johnson and Kendre Harrison, as both will have a chance to play depending on how warm-ups go.

USC has several big names to watch, starting with elite defensive lineman Jahkeem Stewart, who's listed as questionable. The Trojans appear to be trending toward a second straight weekend without freshman phenom wide receiver Trent Mosley.

Further updates will be provided when the teams take the field for warmups.

Final predictions for Oregon vs USC

This game carries massive College Football Playoff and Big Ten Championship implications, and both sides could argue they need the game more. Oregon's loss to Oklahoma State creates far more urgency while USC is looking to prove they're a real contender, and dealing a massive blow to the Ducks could do just that.

While USC is looking to prove they're capable of going on a deep run in the CFP, they're going to have to prove it somewhere else. The USC defense showed major cracks against Rutgers, and if Jamari Johnson plays for the Ducks, Oregon can throw far more talent at this unit. The talent level on both sides is close, but at the end of the day, Dan Lanning has more game changing stars who can take over this game.

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